Candesartan is an angiotensin II Receptor antagonist, widely used in treatment of various disorders like hypertension, heart failure and myocardial infarction. Hydrochlorthiazide belongs to thiazide class of diuretics. It reduces blood volume. Since many years, varied analytical methods were developed both in dosage forms as well as biological fluids in order to estimate their desired pharmacological action. Candesartan variable oral bioavailability is due to its high lipophilic nature. Its estimation for therapeutic efficacy in biological fluids is very critical. A few UV spectrophotometric methodshave been reported to estimate candesartan in bulk formulations. Additionally, capillary electrophoresis methods provided qualitative and quantitative estimation of candesartan. Ultimately, different HPLC and LC-MS/MS methods explained the importance of the methods while estimating candesartan in various biological fluids (e.g. plasma, urine, etc.) as well as in routine drug analysis. This review providesclear and short notes on the various analytical techniquesemployed for determination of candesartan in both in vitro and in vivo conditions
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